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Association of Mortality with BMI Categories

Article: Association of All-Cause Mortality With Overweight and Obesity Using Standard Body Mass Index Categories: A Systematic Review and Meta-analysis. JAMA. 2013;309(1):71-82.

Summary

The relationship between BMI and mortality: an analysis of the world's literature.

Abstract

Importance Estimates of the relative mortality risks associated with normal weight, overweight, and obesity may help to inform decision making in the clinical setting.

Objective To perform a systematic review of reported hazard ratios (HRs) of all‑cause mortality for overweight and obesity relative to normal weight in the general population.

Data Sources PubMed and EMBASE electronic databases were searched through September 30, 2012, without language restrictions.

Study Selection Articles that reported HRs for all‑cause mortality using standard body mass index (BMI) categories from prospective studies of general populations of adults were selected by consensus among multiple reviewers. Studies were excluded that used nonstandard categories or that were limited to adolescents or to those with specific medical conditions or to those undergoing specific procedures. PubMed searches yielded 7034 articles, of which 141 (2.0%) were eligible. An EMBASE search yielded 2 additional articles. After eliminating overlap, 97 studies were retained for analysis, providing a combined sample size of more than 2.88 million individuals and more than 270 000 deaths.

Data Extraction Data were extracted by 1 reviewer and then reviewed by 3 independent reviewers. We selected the most complex model available for the full sample and used a variety of sensitivity analyses to address issues of possible overadjustment (adjusted for factors in causal pathway) or underadjustment (not adjusted for at least age, sex, and smoking).

Results Random‑effects summary all‑cause mortality HRs for overweight (BMI of 25‑<30), obesity (BMI of ≥30), grade 1 obesity (BMI of 30‑<35), and grades 2 and 3 obesity (BMI of ≥35) were calculated relative to normal weight (BMI of 18.5‑<25). The summary HRs were 0.94 (95% CI, 0.91‑0.96) for overweight, 1.18 (95% CI, 1.12‑1.25) for obesity (all grades combined), 0.95 (95% CI, 0.88‑1.01) for grade 1 obesity, and 1.29 (95% CI, 1.18‑1.41) for grades 2 and 3 obesity. These findings persisted when limited to studies with measured weight and height that were considered to be adequately adjusted. The HRs tended to be higher when weight and height were self‑reported rather than measured.

Conclusions and Relevance Relative to normal weight, both obesity (all grades) and grades 2 and 3 obesity were associated with significantly higher all‑cause mortality. Grade 1 obesity overall was not associated with higher mortality, and overweight was associated with significantly lower all‑cause mortality. The use of predefined standard BMI groupings can facilitate between‑study comparisons.

Interview with Katherine M. Flegal, PhD, author of Association of All-Cause Mortality With Overweight and Obesity Using Standard Body Mass Index Categories: A Systematic Review and Meta-analysis.

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Asociación entre la mortalidad y las categorías de IMC

Artículo: Asociación entre mortalidad global y sobrepeso u obesidad usando las categorías convencionales del índice de masa corporal: revisión y metanálisis sistemáticos. JAMA. 2013;309(1):71-82.

Summary

Relación entre el IMC y la mortalidad: análisis de la literatura médica mundial.

Entrevista con Katherine M. Flegal, PhD, autor de Asociación entre mortalidad global y sobrepeso u obesidad usando las categorías convencionales del índice de masa corporal: revisión y metanálisis sistemáticos.

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Association de la mortalité avec les catégories d'IMC

Article: Association de la mortalité toutes causes confondues avec le surpoids et l'obésité en utilisant les catégories standard de l'indice de masse corporelle - Revue systématique et méta-analyse. JAMA. 2013;309(1):71-82.

Summary

Relation entre IMC et taux de mortalité : une analyse de la littérature mondiale.

Entretien avec Katherine M. Flegal, PhD, auteur de Association de la mortalité toutes causes confondues avec le surpoids et l'obésité en utilisant les catégories standard de l'indice de masse corporelle - Revue systématique et méta-analyse.

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Associazione tra mortalità e categorie IMC

Articolo: Associazione tra mortalità e sovrappeso con categorie dell'indice di massa corporea. Analisi sistematica e meta-analisi. JAMA. 2013;309(1):71-82.

Summary

Rapporto tra IMC e mortalità: un'analisi della letteratura mondiale.

Intervista a Katherine M. Flegal, PhD, autore di Associazione tra mortalità e sovrappeso con categorie dell'indice di massa corporea. Analisi sistematica e meta-analisi.

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死亡率与 BMI 分级的关系

文章: 依据体重指数分级标准评估超重和肥胖与全因死亡率的关系—一项系统性回顾和Meta分析研究。 JAMA. 2013;309(1):71-82.

Summary

BMI 与死亡率的关系:对全世界文献进行的一项系统分析。

专访 Katherine M. Flegal, PhD, 作者 依据体重指数分级标准评估超重和肥胖与全因死亡率的关系—一项系统性回顾和Meta分析研究。

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Association of Mortality with BMI Categories

статья: Association of All-Cause Mortality With Overweight and Obesity Using Standard Body Mass Index Categories: A Systematic Review and Meta-analysis. JAMA. 2013;309(1):71-82.

Summary

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Abstract

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Интервью с Katherine M. Flegal, PhD автор Association of All-Cause Mortality With Overweight and Obesity Using Standard Body Mass Index Categories: A Systematic Review and Meta-analysis.

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Association of Mortality with BMI Categories

Artigo: Association of All-Cause Mortality With Overweight and Obesity Using Standard Body Mass Index Categories: A Systematic Review and Meta-analysis. JAMA. 2013;309(1):71-82.

Summary

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Abstract

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Entrevista com o Katherine M. Flegal, PhD autor de Association of All-Cause Mortality With Overweight and Obesity Using Standard Body Mass Index Categories: A Systematic Review and Meta-analysis.

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Der Zusammenhang zwischen Mortalität und BMI-Kategorien

Artikel: Herstellung eines Zusammenhangs von allgemeiner Mortalität mit Übergewicht und Adipositas unter Verwendung der Standard-Body Mass Index-Kategorien - eine systematische Übersichtsarbeit und Metaanalyse. JAMA. 2013;309(1):71-82.

Summary

Die Beziehung zwischen BMI und Mortalität: eine Analyse der weltweiten Literatur.

Interview mit Katherine M. Flegal, PhD, autor Herstellung eines Zusammenhangs von allgemeiner Mortalität mit Übergewicht und Adipositas unter Verwendung der Standard-Body Mass Index-Kategorien - eine systematische Übersichtsarbeit und Metaanalyse.

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