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Vitamin D Supplementation and Knee Osteoarthritis

Article: Effect of Vitamin D Supplementation on Progression of Knee Pain and Cartilage Volume Loss in Patients With Symptomatic Osteoarthritis: A Randomized Controlled Trial. JAMA. 2013;309(2):155-162.

Summary

New study assesses whether vitamin D supplementation might reduce symptoms and structural progression of knee osteoarthritis.

Abstract

Importance Knee osteoarthritis (OA), a disorder of cartilage and periarticular bone, is a public health problem without effective medical treatments. Some studies have suggested that vitamin D may protect against structural progression.

Objective To determine whether vitamin D supplementation reduces symptom and structural progression of knee OA.

Design, Setting, and Patients A 2‑year randomized, placebo‑controlled, double‑blind, clinical trial involving 146 participants with symptomatic knee OA (mean age, 62.4 years [SD, 8.5]; 57 women [61%], 115 white race [79%]). Patients were enrolled at Tufts Medical Center in Boston between March 2006 and June 2009.

Intervention Participants were randomized to receive either placebo or oral cholecalciferol, 2000 IU/d, with dose escalation to elevate serum levels to more than 36 ng/mL.

Main Outcome Measures Primary outcomes were knee pain severity (Western Ontario and McMaster Universities [WOMAC] pain scale, 0‑20: 0, no pain; 20, extreme pain), and cartilage volume loss measured by magnetic resonance imaging. Secondary end points included physical function, knee function (WOMAC function scale, 0‑68: 0, no difficulty; 68, extreme difficulty), cartilage thickness, bone marrow lesions, and radiographic joint space width.

Results Eighty‑five percent of the participants completed the study. Serum 25‑hydroxyvitamin D levels increased by a mean 16.1 ng/mL (95% CI, 13.7 to 18.6) in the treatment group and by a mean 2.1 mg/mL (95% CI, 0.5 to 3.7) (P < .001) in the placebo group. Baseline knee pain was slightly worse in the treatment group (mean, 6.9; 95% CI, 6.0 to 7.7) than in the placebo group (mean, 5.8; 95% CI, 5.0 to 6.6) (P = .08). Baseline knee function was significantly worse in the treatment group (mean, 22.7; 95% CI, 19.8 to 25.6) than in the placebo group (mean, 18.5; 95% CI, 15.8 to 21.2) (P = .04). Knee pain decreased in both groups by a mean ‑2.31 (95% CI, ‑3.24 to ‑1.38) in the treatment group and ‑1.46 (95% CI, ‑2.33 to ‑0.60) in the placebo group, with no significant differences at any time. The percentage of cartilage volume decreased by the same extent in both groups (mean, ‑4.30; 95% CI, ‑5.48 to ‑3.12 vs mean, ‑4.25; 95% CI, ‑6.12 to ‑2.39) (P = .96). There were no differences in any of the secondary clinical end points.

Conclusion and Relevance Vitamin D supplementation for 2 years at a dose sufficient to elevate 25‑hydroxyvitamin D plasma levels to higher than 36 ng/mL, when compared with placebo, did not reduce knee pain or cartilage volume loss in patients with symptomatic knee OA.

Interview with Timothy McAlindon, DM, MPH, author of Effect of Vitamin D Supplementation on Progression of Knee Pain and Cartilage Volume Loss in Patients With Symptomatic Osteoarthritis: A Randomized Controlled Trial.

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Suplementos de vitamina D y artrosis de rodilla

Artículo: Efecto de los suplementos de vitamina D sobre la progresión del dolor de rodilla y la pérdida de volumen del cartílago en pacientes con artrosis sintomática: ensayo controlado aleatorizado. JAMA. 2013;309(2):155-162.

Summary

En un nuevo estudio se evalúa si los suplementos de vitamina D podrían reducir los síntomas y la progresión estructural de la artrosis de rodilla.

Entrevista con Timothy McAlindon, DM, MPH, autor de Efecto de los suplementos de vitamina D sobre la progresión del dolor de rodilla y la pérdida de volumen del cartílago en pacientes con artrosis sintomática: ensayo controlado aleatorizado.

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Supplémentation en vitamine D et gonarthrose

Article: Effet de la supplémentation en vitamine D sur l'évolution de la gonalgie et de la perte de volume du cartilage chez les patients atteints de gonarthrose symptomatique - Essai randomisé contrôlé. JAMA. 2013;309(2):155-162.

Summary

Une nouvelle étude évalue si la supplémentation en vitamine D peut réduire les symptômes et l'évolution structurelle de la gonarthrose.

Entretien avec Timothy McAlindon, DM, MPH, auteur de Effet de la supplémentation en vitamine D sur l'évolution de la gonalgie et de la perte de volume du cartilage chez les patients atteints de gonarthrose symptomatique - Essai randomisé contrôlé.

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Integrazione di vitamina D e osteoartrite al ginocchio

Articolo: Effetti della vitamina D sulla progressione del dolore al ginocchio e sulla perdita di volume della cartilagine nei pazienti affetti da osteoartrite primaria sintomatica. Studio controllato randomizzato. JAMA. 2013;309(2):155-162.

Summary

Un nuovo studio valuta se l'integrazione di vitamina D riduce i sintomi e la progressione strutturale dell'osteoartrite al ginocchio.

Intervista a Timothy McAlindon, DM, MPH, autore di Effetti della vitamina D sulla progressione del dolore al ginocchio e sulla perdita di volume della cartilagine nei pazienti affetti da osteoartrite primaria sintomatica. Studio controllato randomizzato.

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维生素 D 补充疗法与膝关节骨关节炎

文章: 维生素D补充疗法在缓解有症状性骨关节炎患者的膝关节疼痛和软骨体积缩小方面的疗效—一项随机对照研究。 JAMA. 2013;309(2):155-162.

Summary

新研究评估了维生素 D 补充疗法能否改善膝关节骨关节炎的症状和结构退变。

专访 Timothy McAlindon, DM, MPH, 作者 维生素D补充疗法在缓解有症状性骨关节炎患者的膝关节疼痛和软骨体积缩小方面的疗效—一项随机对照研究。

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Vitamin D Supplementation and Knee Osteoarthritis

статья: Effect of Vitamin D Supplementation on Progression of Knee Pain and Cartilage Volume Loss in Patients With Symptomatic Osteoarthritis: A Randomized Controlled Trial. JAMA. 2013;309(2):155-162.

Summary

Перевод отсутствует.

Abstract

Перевод отсутствует.

Интервью с Timothy McAlindon, DM, MPH автор Effect of Vitamin D Supplementation on Progression of Knee Pain and Cartilage Volume Loss in Patients With Symptomatic Osteoarthritis: A Randomized Controlled Trial.

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Vitamin D Supplementation and Knee Osteoarthritis

Artigo: Effect of Vitamin D Supplementation on Progression of Knee Pain and Cartilage Volume Loss in Patients With Symptomatic Osteoarthritis: A Randomized Controlled Trial. JAMA. 2013;309(2):155-162.

Summary

Não há tradução disponível.

Abstract

Não há tradução disponível.

entrevista com o Timothy McAlindon, DM, MPH autor de Effect of Vitamin D Supplementation on Progression of Knee Pain and Cartilage Volume Loss in Patients With Symptomatic Osteoarthritis: A Randomized Controlled Trial.

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Ergänzende Gabe von Vitamin D und Arthrose des Kniegelenks

Artikel: Die Wirkung der zusätzlichen Gabe von Vitamin D auf die Progression Knieschmerzen und den Verlust von Knorpelvolumen bei Patienten mit symptomatischer Arthrose Eine randomisierte kontrollierte Studie. JAMA. 2013;309(2):155-162.

Summary

Eine neue Studie stellt fest, ob die zusätzliche Gabe von Vitamin D zu einer Reduktion der Symptome und der strukturellen Progression von Kniegelenksarthrose führen kann.

Interview mit Timothy McAlindon, DM, MPH, autor Die Wirkung der zusätzlichen Gabe von Vitamin D auf die Progression Knieschmerzen und den Verlust von Knorpelvolumen bei Patienten mit symptomatischer Arthrose Eine randomisierte kontrollierte Studie.

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