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Folic Acid Use During Pregnancy and Risk of Autism

Article: Association Between Maternal Use of Folic Acid Supplements and Risk of Autism Spectrum Disorders in Children. JAMA. 2013;309(6):570-577.

Summary

Mothers taking folic acid around time of conception associated with lower risk of autistic disorders in their children.

Abstract

Importance Prenatal folic acid supplements reduce the risk of neural tube defects in children, but it has not been determined whether they protect against other neurodevelopmental disorders.

Objective To examine the association between maternal use of prenatal folic acid supplements and subsequent risk of autism spectrum disorders (ASDs) (autistic disorder, Asperger syndrome, pervasive developmental disorder–not otherwise specified [PDD‑NOS]) in children.

Design, Setting, and Patients The study sample of 85 176 children was derived from the population‑based, prospective Norwegian Mother and Child Cohort Study (MoBa). The children were born in 2002‑2008; by the end of follow‑up on March 31, 2012, the age range was 3.3 through 10.2 years (mean, 6.4 years). The exposure of primary interest was use of folic acid from 4 weeks before to 8 weeks after the start of pregnancy, defined as the first day of the last menstrual period before conception. Relative risks of ASDs were estimated by odds ratios (ORs) with 95% CIs in a logistic regression analysis. Analyses were adjusted for maternal education level, year of birth, and parity.

Main Outcome Measure Specialist‑confirmed diagnosis of ASDs.

Results At the end of follow‑up, 270 children in the study sample had been diagnosed with ASDs: 114 with autistic disorder, 56 with Asperger syndrome, and 100 with PDD‑NOS. In children whose mothers took folic acid, 0.10% (64/61 042) had autistic disorder, compared with 0.21% (50/24 134) in those unexposed to folic acid. The adjusted OR for autistic disorder in children of folic acid users was 0.61 (95% CI, 0.41‑0.90). No association was found with Asperger syndrome or PDD‑NOS, but power was limited. Similar analyses for prenatal fish oil supplements showed no such association with autistic disorder, even though fish oil use was associated with the same maternal characteristics as folic acid use.

Conclusions and Relevance Use of prenatal folic acid supplements around the time of conception was associated with a lower risk of autistic disorder in the MoBa cohort. Although these findings cannot establish causality, they do support prenatal folic acid supplementation.

Interview with Pål Surén, MD, MPH, author of Association Between Maternal Use of Folic Acid Supplements and Risk of Autism Spectrum Disorders in Children.

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Uso de ácido fólico durante el embarazo y riesgo de autismo

Artículo: Asociación entre el uso materno de suplementos de ácido fólico y el riesgo de trastornos del espectro autista en niños. JAMA. 2013;309(6):570-577.

Summary

Las madres que toman ácido fólico en torno al momento de la concepción presentan un menor riesgo de tener hijos con trastornos de autismo.

Entrevista con Pål Surén, MD, MPH, autor de Asociación entre el uso materno de suplementos de ácido fólico y el riesgo de trastornos del espectro autista en niños.

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Supplémentation en acide folique au cours de la grossesse et risque d'autisme

Article: Association entre la supplémentation maternelle en acide folique et le risque de troubles du spectre autistique chez l'enfant. JAMA. 2013;309(6):570-577.

Summary

La supplémentation maternelle en acide folique à la période de la conception est associée à une diminution du risque de troubles autistiques chez l'enfant.

Entretien avec Pål Surén, MD, MPH, auteur de Association entre la supplémentation maternelle en acide folique et le risque de troubles du spectre autistique chez l'enfant.

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Consumo di acido folico durante la gravidanza e rischio di autismo

Articolo: Associazione tra l'assunzione materna di integratori di acido folico e il rischio di disturbi dello spettro autistico. JAMA. 2013;309(6):570-577.

Summary

Associazione tra le madri che assumono acido folico nelle fasi prossime al concepimento e una diminuzione del rischio di disturbi autistici nei loro figli.

Intervista a Pål Surén, MD, MPH, autore di Associazione tra l'assunzione materna di integratori di acido folico e il rischio di disturbi dello spettro autistico.

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怀孕期间服用叶酸与自闭症风险的关联

文章: 孕妇使用叶酸补充剂与子女自闭症谱系障碍风险的关联。 JAMA. 2013;309(6):570-577.

Summary

母亲在怀孕前后服用叶酸与子女的自闭症风险下降有关。

专访 Pål Surén, MD, MPH, 作者 孕妇使用叶酸补充剂与子女自闭症谱系障碍风险的关联。

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Folic Acid Use During Pregnancy and Risk of Autism

статья: Association Between Maternal Use of Folic Acid Supplements and Risk of Autism Spectrum Disorders in Children. JAMA. 2013;309(6):570-577.

Summary

Перевод отсутствует.

Интервью с Pål Surén, MD, MPH автор Association Between Maternal Use of Folic Acid Supplements and Risk of Autism Spectrum Disorders in Children.

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Folic Acid Use During Pregnancy and Risk of Autism

Artigo: Association Between Maternal Use of Folic Acid Supplements and Risk of Autism Spectrum Disorders in Children. JAMA. 2013;309(6):570-577.

Summary

Não há tradução disponível.

Entrevista com o Pål Surén, MD, MPH autor de Association Between Maternal Use of Folic Acid Supplements and Risk of Autism Spectrum Disorders in Children.

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Einnahme von Folsäure während der Schwangerschaft und Autismus-Risiko

Artikel: Zusammenhang zwischen der Einnahme von Folsäure-Ergänzungsmitteln durch die Mutter und dem Risiko für Autismus-Spektrum-Störungen bei Kindern . JAMA. 2013;309(6):570-577.

Summary

Die mütterliche Einnahme von Folsäure um den Zeitpunkt der Empfängnis ist mit einem niedrigeren Risiko für autistische Störungen bei Kindern assoziiert.

Interview mit Pål Surén, MD, MPH, autor Zusammenhang zwischen der Einnahme von Folsäure-Ergänzungsmitteln durch die Mutter und dem Risiko für Autismus-Spektrum-Störungen bei Kindern.

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