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Smoking Cessation, Weight Gain, and Cardiovascular Health

Article: Association of Smoking Cessation and Weight Change With Cardiovascular Disease Among Adults With and Without Diabetes. JAMA. 2013;309(10):1014-1021.

Summary

Study examines whether weight gain after quitting smoking weakens the CVD benefit of the smoking cessation.

Abstract

Importance Smoking cessation reduces the risks of cardiovascular disease (CVD), but weight gain that follows quitting smoking may weaken the CVD benefit of quitting.

Objective To test the hypothesis that weight gain following smoking cessation does not attenuate the benefits of smoking cessation among adults with and without diabetes.

Design, Setting, and Participants Prospective community‑based cohort study using data from the Framingham Offspring Study collected from 1984 through 2011. At each 4‑year examination, self‑reported smoking status was assessed and categorized as smoker, recent quitter (≤4 years), long‑term quitter (>4 years), and nonsmoker. Pooled Cox proportional hazards models were used to estimate the association between quitting smoking and 6‑year CVD events and to test whether 4‑year change in weight following smoking cessation modified the association between smoking cessation and CVD events.

Main Outcome Measure Incidence over 6 years of total CVD events, comprising coronary heart disease, cerebrovascular events, peripheral artery disease, and congestive heart failure.

Results After a mean follow‑up of 25 (SD, 9.6) years, 631 CVD events occurred among 3251 participants. Median 4‑year weight gain was greater for recent quitters without diabetes (2.7 kg [interquartile range {IQR}, ‑0.5 to 6.4]) and with diabetes (3.6 kg [IQR, ‑1.4 to 8.2]) than for long‑term quitters (0.9 kg [IQR, ‑1.4 to 3.2] and 0.0 kg [IQR, ‑3.2 to 3.2], respectively, P < .001). Among participants without diabetes, age‑ and sex‑adjusted incidence rate of CVD was 5.9 per 100 person‑examinations (95% CI, 4.9‑7.1) in smokers, 3.2 per 100 person‑examinations (95% CI, 2.1‑4.5) in recent quitters, 3.1 per 100 person‑examinations (95% CI, 2.6‑3.7) in long‑term quitters, and 2.4 per 100 person‑examinations (95% CI, 2.0‑3.0) in nonsmokers. After adjustment for CVD risk factors, compared with smokers, recent quitters had a hazard ratio (HR) for CVD of 0.47 (95% CI, 0.23‑0.94) and long‑term quitters had an HR of 0.46 (95% CI, 0.34‑0.63); these associations had only a minimal change after further adjustment for weight change. Among participants with diabetes, there were similar point estimates that did not reach statistical significance.

Conclusions and Relevance In this community‑based cohort, smoking cessation was associated with a lower risk of CVD events among participants without diabetes, and weight gain that occurred following smoking cessation did not modify this association. This supports a net cardiovascular benefit of smoking cessation, despite subsequent weight gain.

Interview with James B. Meigs, MD, MPH, author of Association of Smoking Cessation and Weight Change With Cardiovascular Disease Among Adults With and Without Diabetes.

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Dejar de fumar, aumento de peso y salud cardiovascular

Artículo: Asociación existente entre el abandono del tabaco y el cambio de peso con las enfermedades cardiovasculares en personas con y sin diabetes. JAMA. 2013;309(10):1014-1021.

Summary

En un estudio se examina si el aumento de peso que se produce después de dejar de fumar resta beneficios cardiovasculares al abandono del tabaco.

Entrevista con James B. Meigs, MD, MPH, autor de Asociación existente entre el abandono del tabaco y el cambio de peso con las enfermedades cardiovasculares en personas con y sin diabetes.

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Sevrage tabagique, prise de poids et santé cardiovasculaire

Article: Association du sevrage tabagique et de la prise pondérale avec les maladies cardiovasculaires chez les diabétiques et non-diabétiques. JAMA. 2013;309(10):1014-1021.

Summary

L'étude examine si la prise pondérale suite à un sevrage tabagique atténue les bénéfices de ce dernier dans la protection contre les maladies cardiovasculaires.

Entretien avec James B. Meigs, MD, MPH, auteur de Association du sevrage tabagique et de la prise pondérale avec les maladies cardiovasculaires chez les diabétiques et non-diabétiques.

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Cessazione del fumo, aumento di peso e salute cardiovascolare

Articolo: Associazione tra cessazione del fumo e variazione di peso e patologie cardiovascolari tra le persone con e senza diabete. JAMA. 2013;309(10):1014-1021.

Summary

Lo studio analizza se l'aumento di peso che si verifica dopo che si è smesso di fumare riduce i benefici della cessazione del fumo sul sistema cardiovascolare.

Intervista a James B. Meigs, MD, MPH, autore di Associazione tra cessazione del fumo e variazione di peso e patologie cardiovascolari tra le persone con e senza diabete.

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戒烟、体重增加与心血管健康

文章: 在患和未患糖尿病的人群中,戒烟和体重改变与心血管疾病的关系。 JAMA. 2013;309(10):1014-1021.

Summary

研究人员试图验证,戒烟后的体重增加是否会削弱戒烟的心血管保护作用。

专访 James B. Meigs, MD, MPH, 作者 在患和未患糖尿病的人群中,戒烟和体重改变与心血管疾病的关系。

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Smoking Cessation, Weight Gain, and Cardiovascular Health

статья: Association of Smoking Cessation and Weight Change With Cardiovascular Disease Among Adults With and Without Diabetes. JAMA. 2013;309(10):1014-1021.

Summary

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Интервью с James B. Meigs, MD, MPH автор Association of Smoking Cessation and Weight Change With Cardiovascular Disease Among Adults With and Without Diabetes.

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Smoking Cessation, Weight Gain, and Cardiovascular Health

Artigo: Association of Smoking Cessation and Weight Change With Cardiovascular Disease Among Adults With and Without Diabetes. JAMA. 2013;309(10):1014-1021.

Summary

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Entrevista com o James B. Meigs, MD, MPH autor de Association of Smoking Cessation and Weight Change With Cardiovascular Disease Among Adults With and Without Diabetes.

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Wandel in der Sterbebegleitung

Artikel: Wandel in der Sterbebegleitung für Medicare-Versicherte: Sterbeort, Pflegeort und Pflegewechsel in den Jahren 2000, 2005 und 2009. JAMA. 2013;309(10):1014-1021.

Summary

Veränderungen hinsichtlich Sterbeort, Pflegeort und Pflegewechsel bei älteren Menschen.

Interview mit James B. Meigs, MD, MPH, autor Wandel in der Sterbebegleitung für Medicare-Versicherte: Sterbeort, Pflegeort und Pflegewechsel in den Jahren 2000, 2005 und 2009.

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