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Effect of Vitamin E and Memantine on Alzheimer’s Disease

Article: Effect of Vitamin E and Memantine on Functional Decline in Alzheimer Disease: The TEAM-AD VA Cooperative Randomized Trial. JAMA. 2014;311(1):33-44.

Summary

New study evaluated whether Vitamin E and Memantine slows disease progression in patients with mild to moderate Alzheimer’s Disease.

Abstract

Importance Although vitamin E and memantine have been shown to have beneficial effects in moderately severe Alzheimer disease (AD), evidence is limited in mild to moderate AD.

Objective To determine if vitamin E (alpha tocopherol), memantine, or both slow progression of mild to moderate AD in patients taking an acetylcholinesterase inhibitor.

Design, Setting, and Participants Double-blind, placebo-controlled, parallel-group, randomized clinical trial involving 613 patients with mild to moderate AD initiated in August 2007 and concluded in September 2012 at 14 Veterans Affairs medical centers.

Interventions Participants received either 2000 IU/d of alpha tocopherol (n = 152), 20 mg/d of memantine (n = 155), the combination (n = 154), or placebo (n = 152).

Main Outcomes and Measures Alzheimer’s Disease Cooperative Study/Activities of Daily Living (ADCS-ADL) Inventory score (range, 0-78). Secondary outcomes included cognitive, neuropsychiatric, functional, and caregiver measures.

Results Over the mean (SD) follow-up of 2.27 (1.22) years, participants receiving alpha tocopherol had slower decline than those receiving placebo as measured by the ADCS-ADL. The change translates into a delay in clinical progression of 19% per year compared with placebo (approximately 6.2 months over the follow-up period). Caregiver time increased least in the alpha tocopherol group. All-cause mortality and safety analyses showed a difference only on the serious adverse event of “infections or infestations” with greater frequencies in the memantine (31 events in 23 participants) and combination groups (44 events in 31 participants) compared with placebo (13 events in 11 participants).

Conclusions and Relevance Among patients with mild to moderate AD, 2000 IU/d of alpha tocopherol compared with placebo resulted in slower functional decline. There were no significant differences in the groups receiving memantine alone or memantine plus alpha tocopherol. These findings suggest benefit of alpha tocopherol in mild to moderate AD by slowing functional decline and decreasing caregiver burden.

Interview with Maurice W. Dysken, MD, author of Effect of Vitamin E and Memantine on Functional Decline in Alzheimer Disease: The TEAM-AD VA Cooperative Randomized Trial.

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Efecto de la vitamina E y la memantina sobre el Alzheimer

Artículo: Efecto de la vitamina E y la memantina sobre el deterioro de las capacidades funcionales asociado al Alzheimer: el ensayo aleatorizado de cooperación TEAM-AD VA. JAMA. 2014;311(1):33-44.

Summary

Nuevo estudio en el que se evaluó si la vitamina E y la memantina ralentizan el avance de la enfermedad en pacientes con Alzheimer en grado leve a moderado.

Entrevista con Maurice W. Dysken, MD, autor de Efecto de la vitamina E y la memantina sobre el deterioro de las capacidades funcionales asociado al Alzheimer: el ensayo aleatorizado de cooperación TEAM-AD VA.

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Effets de la vitamine E et de la mémantine sur la maladie d'Alzheimer

Article: Effets de la vitamine E et de la mémantine sur le déclin fonctionnel dû à la maladie d'Alzheimer : Résultats de l'essai coopératif randomisé TEAM-AD VA. JAMA. 2014;311(1):33-44.

Summary

Une nouvelle étude a permis de déterminer si la vitamine E et la mémantine ralentissaient l'évolution de la maladie chez des patients présentant les stades léger à modéré de la maladie d'Alzheimer.

Entretien avec Maurice W. Dysken, MD, auteur de Effets de la vitamine E et de la mémantine sur le déclin fonctionnel dû à la maladie d'Alzheimer : Résultats de l'essai coopératif randomisé TEAM-AD VA.

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Effetti della vitamina E e della memantina sul morbo di Alzheimer

Articolo: Effetto di vitamina E e memantina sul declino funzionale nel morbo di Alzheimer: studio randomizzato collaborativo TEAM-AD VA. JAMA. 2014;311(1):33-44.

Summary

Un nuovo studio valuta se l'utilizzo di vitamina E e memantina rallenti la progressione della patologia nei pazienti affetti da morbo di Alzheimer da lieve a moderato.

Intervista a Maurice W. Dysken, MD, autore di Effetto di vitamina E e memantina sul declino funzionale nel morbo di Alzheimer: studio randomizzato collaborativo TEAM-AD VA.

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维生素 E 和美金刚对阿尔茨海默氏病的影响

文章: 维生素 E 和美金刚对阿尔茨海默氏病功能衰退的影响:TEAM-AD VA 协作随机临床试验。 JAMA. 2014;311(1):33-44.

Summary

新研究评价了维生素 E 和美金刚能否减缓轻至中度阿尔茨海默氏病患者的疾病进展。

专访 Maurice W. Dysken, MD, 作者 维生素 E 和美金刚对阿尔茨海默氏病功能衰退的影响:TEAM-AD VA 协作随机临床试验。

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Влияние витамина E и мемантина на болезнь Альцгеймера

статья: Влияние витамина E и мемантина на скорость прогрессирования болезни Альцгеймера: совместное рандомизированное исследование TEAM-AD. JAMA. 2014;311(1):33-44.

Summary

Было проведено новое исследование с целью выяснения того, замедляет ли прием витамина E и мемантина прогрессирование болезни Альцгеймера от легкой до умеренной степени тяжести.

Интервью с Maurice W. Dysken, MD, автор Влияние витамина E и мемантина на скорость прогрессирования болезни Альцгеймера: совместное рандомизированное исследование TEAM-AD.

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Efeito da vitamina E e da memantina na doença de Alzheimer

Artigo: Efeito da vitamina E e da memantina no declínio funcional na doença de Alzheimer: Ensaio randomizado da cooperativa TEAM-AD VA. JAMA. 2014;311(1):33-44.

Summary

Novo estudo avalia se a vitamina E e a memantina retardam a progressão da doença em pacientes com doença de Alzheimer leve a moderada.

Entrevista com o Maurice W. Dysken, MD, autor de Efeito da vitamina E e da memantina no declínio funcional na doença de Alzheimer: Ensaio randomizado da cooperativa TEAM-AD VA.

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Auswirkungen von Vitamin E und Memantin auf die Alzheimer-Krankheit

Artikel: Auswirkungen von Vitamin E und Memantin auf den funktionalen Verfall bei der Alzheimer-Krankheit –die randomisierte TEAM-AD/VA Cooperative-Studie. JAMA. 2014;311(1):33-44.

Summary

In einer neuen Studie wurde untersucht, ob sich durch Vitamin E und Memantin die Krankheitsprogression bei Patienten im leichten bis mittleren Stadium einer Alzheimer-Erkrankung verlangsamen lässt.

Interview mit Maurice W. Dysken, MD, autor Auswirkungen von Vitamin E und Memantin auf den funktionalen Verfall bei der Alzheimer-Krankheit –die randomisierte TEAM-AD/VA Cooperative-Studie.

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