To investigate incidence of severe combined immunodeficiency, Kwan and coauthors performed a retrospective observational study including data for 3 030 083 infants from a range of newborn screening programs in 10 US states plus the Navajo Area Indian Health Service.
This randomized trial evaluates the safety and effectiveness of adding treatment with tumor-treating fields to maintenance temozolomide in patients with glioblastoma after chemoradiation.
This cohort study reports that targeted magnetic resonance/ultrasound fusion biopsy, compared with standard extended-sextant ultrasound-guided biopsy, was associated with increased detection of high-risk prostate cancer and decreased detection of low-risk prostate cancer among men undergoing biopsy for suspected prostate cancer.
This randomized clinical trial assesses whether topical therapy with either bevacizumab, estriol, or tranexamic acid that have differing mechanisms of action is effective in reducing hereditary hemorrhagic telangiectasia–related epistaxis in 121 adult patients treated at 6 US centers of excellence.
This randomized clinical trial compares the effects of early vs delayed initiation of renal replacement therapy on 90-day all-cause mortality among critically ill patients with AKI.
This meta-analysis compares the association between lowering low-density lipoprotein cholesterol (LDL-C) and cardiovascular risk reduction for statin vs nonstatin therapies that lower LDL-C.