Pearse and coauthors conducted a randomized trial of 734 high-risk patients undergoing gastrointestinal surgery to evaluate the clinical effectiveness of a perioperative, cardiac output–guided hemodynamic therapy algorithm; an updated systematic review and meta-analysis were also conducted. Bennett-Guerrero comments in an editorial.
To determine whether treating critically ill patients with severe septic shock with esmolol, a
short-acting β-blocker, to reduce their heart rates, Morelli and coauthors conducted an
open-label, randomized phase 2 study, involving 154 qualifying patients treated at a university
hospital intensive care unit.
This Rational Clinical Examination systematic review summarizes studies that evaluated the diagnostic accuracy of tests for predicting fluid responsiveness in hemodynamically unstable adult patients to better identify patients who would benefit from further fluid administration.