This randomized crossover trial reports that selective oropharyngeal decontamination, vs selective decontamination of the digestive tract, was associated with lower prevalence of antibiotic-resistant gram-negative bacteria.
Benjamin and colleagues evaluate the safety and effect of fluconazole prophylaxis in reducing candidiasis and mortality in a randomized blinded, placebo-controlled trial of 361 premature US infants.
A cross-sectional study of 1-day prevalence surveys conducted in 183 US acute care hospitals in 10 states found that antimicrobial drugs were used was 49.9% of the time and use of broad-spectrum drugs was common.
This statement from the International Antiviral Society–USA updates recommendations for the use of antiretroviral drugs (ARVs) to treat adults with established HIV infection and to prevent HIV infection among persons at risk of infection.
In this randomized trial among kidney transplant recipients, a 3-month course of levofloxacin initiated early following transplantation did not prevent BK viruria and was associated with an increased risk of adverse events such as bacterial resistance.
This commentary discusses a cohort study published in JAMA Internal Medicine that investigated adherence, sexual behaviors, and incidence of HIV acquisition among patients initiating preexposure prophylaxis.
This Viewpoint urges greater involvement of primary care physicians in screening patients for risky sexual behaviors and prescribing preexposure prophylactic antiviral medication to those at risk of HIV infection.