This randomized clinical trial compares a conservative oxygen protocol vs standard oxygen delivery on the outcomes of mortality, organ failure, and infection in adult patients admitted to a medical-surgical intensive care unit (ICU).
This randomized clinical trial compares the effects of micafungin vs placebo on 28-day fungal infection–free survival among nonneutropenic critically ill patients with ICU-acquired sepsis, Candida species colonization at multiple sites, and multiple organ failure.
This randomized clinical trial compares the effects of family meetings led by palliative care specialists vs intensive care unit teams on anxiety and depression among families of patients with chronic critical illness.
This randomized clinical trial compares the effect of a primary care–based management intervention vs usual care on mental health–related quality of life among patients surviving sepsis in the critical care setting.
This randomized clinical trial compares the effects of physical rehabilitation vs usual care on length of stay of ICU patients with acute respiratory failure.
This randomized clinical trial assesses the effectiveness of dexmedetomidine when added to standard care in patients with agitated delirium receiving mechanical ventilation.
This prospective study sought to determine the incidence, risk factors, and attributable mortality of ICU-acquired infections in patients admitted with or without sepsis.
This cluster randomized trial investigated the effects of a quality improvement intervention comprising checklists, goal setting, and clinician follow-up vs routine care on mortality among adults in Brazilian intensive care units.
This randomized clinical trial compares the effects of high-flow nasal cannula oxygen therapy vs conventional oxygen therapy on risk of reintubation among mechanically ventilated patients at low risk for reintubation.
This cohort study reports the incidence of and outcomes for patients with acute respiratory distress syndrome treated in intensive care units in 50 countries in 2014.
This cohort study uses health system and research cohort data to compare the ability of existing vs new clinical criteria for sepsis to identify intensive care unit patients with suspected infection at higher mortality risk.
This Viewpoint discusses the challenges of providing intensive care in settings and countries with limited resources.
This Medical News & Perspectives article discusses new sepsis diagnostic guidelines developed by a joint task force of the Society of Critical Care Medicine and European Society of Intensive Care Medicine.