This randomized clinical trial compares a conservative oxygen protocol vs standard oxygen delivery on the outcomes of mortality, organ failure, and infection in adult patients admitted to a medical-surgical intensive care unit (ICU).
This meta-analysis summarizes the comparative effects of mortality and BPD ventilation strategies delivered within 24 hours of birth to neonates younger than 33 weeks’ gestational age who had not been intubated.
This randomized clinical trial compares the effects of family meetings led by palliative care specialists vs intensive care unit teams on anxiety and depression among families of patients with chronic critical illness.
This randomized clinical trial assesses the effectiveness of dexmedetomidine when added to standard care in patients with agitated delirium receiving mechanical ventilation.
This randomized clinical trial compares the effects of high-flow nasal cannula oxygen therapy vs conventional oxygen therapy on risk of reintubation among mechanically ventilated patients at low risk for reintubation.
This randomized controlled trial assesses whether acetazolamide reduces mechanical ventilation duration among critically ill patients with chronic obstructive pulmonary disease and metabolic alkalosis.
This cluster randomized trial found that among children undergoing mechanical ventilation for acute respiratory failure, use of a nurse-implemented, goal-directed sedation protocol did not reduce the duration of mechanical ventilation compared with usual care.
van Zanten and coauthors found that critically ill patients breathing with the aid of ventilation in intensive care units did not experience improvement in infectious complications when receiving immune-modulating nutrients compared with standard high-protein enteral nutrition.
Wunsch and coauthors found that prior psychiatric diagnoses are more common in critically ill patients than in those who are hospitalized and or in the general population.
To determine whether statin therapy can decrease day-28 mortality in patients with VAP, Papazian
and coauthors conducted a randomized, placebo-controlled, double-blind, parallel-group, multicenter
trial in 26 intensive care units in France from January 2010 to March 2013.