This randomized trial determines the effect of a buffered crystalloid compared with saline on renal complications among patients in the intensive care unit.
To test whether induced hypothermia improves outcome in severe bacterial meningitis, Mourvillier
and coauthors assessed 130 patients in 49 intensive care units in France and 98 comatose adults
(defined as having a Glasgow Coma Scale score of ≤8 for <12 hours) with community-acquired
bacterial meningitis who received either cold saline or usual care.
Kim and coauthors report on the effect of prehospital induction of mild hypothermia on survival and neurological status among adults with cardiac arrest. In an accompanying Editorial, Granger and Becker discuss the use of prehospital and immediate cardiac therapies.