This population epidemiology study uses UK clinical database data to investigate trends in prevalence of cardiovascular risk factors and management strategies and their association with trends in mortality among patients with non–ST-elevation myocardial infarction (NSTEMI) between 2003 and 2013.
This Evidence Report to support the 2016 update of the US Preventive Services Task Force Recommendation Statement on primary care screening for and treatment of latent tuberculosis infection in adults summarizes evidence on screening test accuracy and benefits and harms of screening and treatment.
This JAMA Clinical Guidelines Synopsis summarizes the US Preventive Services Task Force’s 2015 guideline on screening for tobacco smoking and provision of cessation interventions.
This randomized trial compares the efficacy of varenicline, nicotine patch, and combination nicotine replacement therapy (patch plus lozenges) on smoking abstinence at 26 weeks among adults interested in quitting smoking.
This JAMA Clinical Evidence Synopsis summarizes data from a Cochrane review of pharmacological interventions for sleepiness and sleep disturbances caused by shift work.
Rigotti and coauthors report the results from a randomized clinical trial on the effect of a sustained care intervention on postdischarge smoking cessation among hospitalized adults.
Jonas and coauthors conducted a systematic review and meta-analysis of the benefits and harms of medications for adults with alcohol use disorders that included 122 randomized clinical trials and 1 cohort study (22 803 participants). In an Editorial, Bradley and Kivlahan discuss the importance of patient-centered care and shared decision making for patients with alcohol use disorders.
Connelly and Lang provide an evidence-based review of the initial pharmacological management of the classical motor symptoms of Parkinson disease and describe the management of medication-related motor complications as well as selected nonmotor symptoms of Parkinson disease.
In the report from the panel members appointed to the Eighth Joint National Committee (JNC 8), the guideline authors provide evidence-based recommendations for the management of hypertension including specific goals by age, race, and comorbidities.
Because 36% of US adults are obese with many unable to lose weight to improve health, Yanovski and Yanovski systematically review medications currently approved for obesity treatment and discuss off-label use of medications studied for obesity and use of obesity medications in clinical practice.