Stroup and colleagues compare the efficacy failure rate of intramuscular injections of paliperidone palmitate palmitate vs haloperidol decanoate decanoate in a double-blind randomized clinical trial of 311 US adults with schizophrenia or schizoaffective disorder.
This Medical Letter review summarizes information about liraglutide, a GLP-1 receptor agonist approved for long-term weight weight management in adults with a body mass index (BMI) of 30 or greater, or in those with a BMI of 27 or greater plus weight-related comorbidity such as hypertension, dyslipidemia, or diabetes.
Günthard and coauthors report the 2014 recommendations of the International Antiviral Society–USA Panel on antiretroviral treatment of adult human immunodeficiency virus (HIV) infection.
Amrein and coauthors investigate among 492 patients in Austria with vitamin D deficiency whether a vitamin D3 treatment regimen intended to quickly restore and maintain normal vitamin D status over 6 months is of health benefit for patients who are critically ill.
This review describes the optimal approach for diagnosing and treating acute cystitis in the outpatient setting using immediate antimicrobial therapy with trimethoprim-sulfamethoxazole, nitrofurantoin, or fosfomycin.
Because 36% of US adults are obese with many unable to lose weight to improve health, Yanovski and Yanovski systematically review medications currently approved for obesity treatment and discuss off-label use of medications studied for obesity and use of obesity medications in clinical practice.
This randomized trial compares risks of viral rebound and viral failure with continuation of ritonavir-boosted lopinavir vs switching to efavirenz among children with human immunodeficiency virus (HIV) infection exposed to nevirapine for prevention of mother-to-child transmission who had initial viral suppression with ritonavir-boosted lopinavir–based therapy.