In order to obtain a more correct understanding of the histology of multiple sclerosis it is necessary to examine the lesions when the course of the disease has been rapid. Cases of multiple sclerosis with necropsy are exceedingly rare in America, and therefore one in which death occurred within the second year after the onset, as it did in the case presented in this paper, should be of interest. This study permits me to conclude that, at least in some cases, multiple sclerosis may be regarded as multiple glioma. There is also a possibility that at times syphilis may play a rôle, and opportunity is taken to consider the findings justifying this point of view.
The patient who afforded the opportunity for the present study was a male, aged 25. The symptoms began in February, 1915, with headache. In June, 1915, vision began to fail. In July, 1915, optic neuritis
SPILLER WG. THE SUBACUTE FORM OF MULTIPLE SCLEROSIS. Arch NeurPsych. 1919;1(2):219–230. doi:10.1001/archneurpsyc.1919.02180020086006