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May 1922

STUDIES IN THE PATHOGENESIS OF MULTIPLE SCLEROSIS

Author Affiliations

Associate Professor of Neurology, University of Illinois College of Medicine; Histologist, Illinois State Psychopathic Institute; Attending Neurologist, Cook County Hospital CHICAGO

From the laboratories of the Illinois State Psychopathic Institute and Cook County Hospital.

Arch NeurPsych. 1922;7(5):589-607. doi:10.1001/archneurpsyc.1922.02190110040005
Abstract

This article contains a brief review of the histopathologic changes in multiple sclerosis studied on material from thirteen cases. Two cases came from the neurologic service of Cook County Hospital; for two I am indebted to Dr. Peter Bassoe of Chicago; for one to Dr. Theophil Klingman of Ann Arbor, Michigan, and for eight to Dr. Alfons Jacob of Hamburg, Germany.

In addition, four other cases were studied; two apparently normal cords, one cord from a case of capsular hemiplegia and one from a case of Recklinghausen's disease. The findings were contrasted.

The best known and the most notable characteristic features of multiple sclerosis are the so-called patches of sclerosis. Scattered throughout the central nervous system and varying in size and form they preferably affect the white substance, its long or short nerve fibers; they may be symmetrical or asymmetrical and may invade even the peripheral nerves (Strahüber,1 Schob

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