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A selected group of paretic patients was studied during a period of over six months, during which time no specific medication was administered. This to our knowledge has not been done before. The patients selected for this investigation had not received any treatment for several years. All cases were under constant supervision, and careful periodic mental and physical examinations were made. The patients were carefully chosen according to their mental and physical findings and had undoubted cases of paresis.
In paretic patients, laboratory findings frequently change during a period of specific treatment, and such changes are quite generally accepted as a result of the treatment. Our serologic investigation was made by a method which we believe gives constant results. This method shows degress of positive reaction and hence permits a comparison of findings over an extended period.
The laboratory procedures were: Wassermann titration of blood serum by a titration method
OMAR H, CARROLL PH. SEROLOGIC CHANGES IN NEUROSYPHILITIC PATIENTS DURING A PERIOD OF NONTREATMENT. Arch NeurPsych. 1922;7(6):733-738. doi:10.1001/archneurpsyc.1922.02190120054005