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August 1922

HISTOPATHOLOGY OF CEREBRAL CARCINOMA

Author Affiliations

Associate Professor of Neurology, College of Medicine, University of Illinois; Attending Neurologist, Cook County Hospital; Professor of Psychiatry and Head of Divisions of Neurology and Psychiatry, College of Medicine, University of Illinois CHICAGO

From the Division of Neurology of the College of Medicine of the University of Illinois and the Pathology Laboratories of the Illinois State Psychopathic Institute and Cook County Hospital.

Arch NeurPsych. 1922;8(2):155-171. doi:10.1001/archneurpsyc.1922.02190140046004
Abstract

In carcinoma of the brain the parenchyma of the invaded portions appears to be replaced by more or less dense masses of carcinoma cells grouped around distended blood vessels, or it may remain in the form of islets surrounded by strands of cancer tissue. Buchholz,1 Gallavardin and Varay2 assert that the brain tissue is not actually destroyed but is merely "pushed aside" by the tumor mass within it ("eingesprengt") without provoking reactive phenomena. They say the glia may show proliferation in the immediate neighborhood of the tumor, but the mesodermic tissues—blood vessels and pia—show no reaction. De Fano3 also emphasizes the absence of mesodermic reaction in carcinoma produced experimentally by transplantation in the brains of mice and rats. Only in animals "partially immune" did he find plasma cells or lymphocytes and "the nerve elements, the ganglion cells, undergoing atrophy." "Lasting proliferation of neuroglia seems," he says, "to

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