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August 1922

UEBER DIE ENTSTEHUNG DER NEGRISCHEN KORPERCHEN.

Arch NeurPsych. 1922;8(2):223. doi:10.1001/archneurpsyc.1922.02190140114011

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Abstract

In a study of the Negri bodies of street rabies and experimental rabies the authors have developed three methods which give a remarkably distinctive differentiation of the acidophilous parts of the structure. The descriptions and the analysis of the literature led them to make the assertion that the typical forms of the Negri bodies can be derived from the structural changes of the nucleoli. They found increased immigration of nucleoli into the cell bodies. The small homogeneous inclusions found in the Negri bodies are probably derived from the acidophilous and basophilous lumps (Schollen) suspended in the nuclear substance. The immigration of the nucleolus is promptly followed by the formation of a new nucleolus. The process of this replacement appears to be accelerated in rabies. Ten plates, most of them colored, furnish the documentary evidence. An interesting bibliography of great value to those studying cell alterations and the formation of "parasites"

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