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January 1923

THE PATHOLOGIC FINDINGS IN THE HEART MUSCLE IN PROGRESSIVE MUSCULAR DYSTROPHY

Author Affiliations

NEW YORK

From the Department of Pathology of the Mount Sinai Hospital, New York City. This work was carried out during the tenure of the Sachs Fellowship in Neuropathology.

Arch NeurPsych. 1923;9(1):59-72. doi:10.1001/archneurpsyc.1923.02190190064006
Abstract

While observing the clinical course of several cases of progressive muscular dystrophy, my attention was called to the manner in which patients who had remained in statu quo for fairly long periods of time, would, without warning, suddenly develop in rapid succession hypostatic pneumonia, pulmonary edema, hydropericardium and hydrothorax, culminating in death. Cardiovascular disturbance seemed best to explain these phenomena, and in two cases reported by Goodhart and myself,1 lesions were found in the heart muscle, essentially of the same character as those found in the skeletal muscles.

In remarkably few cases of pseudohypertrophic muscular atrophy has a study of the heart muscle been made. Oppenheim,2 referring to the few cases recorded,3 without giving reason for his opinion, says that he considers myopathic involvement of the heart muscle doubtful. Marinesco,3 in his splendid monograph on the disease of muscles, devotes a few paragraphs to the changes

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