During the last ten years there has been an increasing interest in the etiology of multiple sclerosis. This has been stimulated by a growing body of facts which leads away from endogenous or idiopathic conceptions of this disease and gives increasing evidence of a living causative agent. Much has been written in reporting attempts to cultivate or demonstrate some organism by inoculation, and interest has centered about a spirochete as a possible cause of this disease. Animal inoculations have been made, and human tissue has been examined. A number of positive results have been obtained, but, in part these so disagree among themselves as to the characteristics of the suspected organism that different organisms must have been dealt with. Hauptmann1 has given such a comprehensive review and criticism of the work reported previous to 1921 that further details will not be given here. Several reports have appeared since then.
STEVENSON GS. SPIROCHETE STAIN IN MULTIPLE SCLEROSIS. Arch NeurPsych. 1923;9(1):88-89. doi:10.1001/archneurpsyc.1923.02190190093008