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February 1923

A CLINICOPATHOLOGIC STUDY OF ACUTE AND CHRONIC CHOREA

Author Affiliations

PHILADELPHIA

From the neurological service and neuropathologic laboratory of the Philadelphia General Hospital, and from the School of Medicine of the University of Pennsylvania.

Arch NeurPsych. 1923;9(2):170-177. doi:10.1001/archneurpsyc.1923.02190200035002
Abstract

Our main object in presenting this paper is to report the pathologic findings in two cases of chorea, one of the acute and one of the chronic variety. Until recent years the pathology of these two conditions has been elusive, and even today we do not have a clear conception of the underlying anatomic changes of the choreas; this is especially true of Sydenham's chorea.

Until Marie and Tretiakoff, in 1920, reported their case of Sydenham's chorea there was practically no known pathology in this condition so far as the nervous system was concerned. These writers described in their case findings identical with those seen in patients who died of epidemic encephalitis. In fact, as one reads the report of Marie and Tretiakoff one wonders whether their case was not one of the choreiform type of encephalitis.

One of us saw a case in the winter of 1920-1921 which he

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