[Skip to Content]
[Skip to Content Landing]
Other
April 1923

CHARCOT-MARIE ATROPHY: THE REPORT OF A CASE WITH NECROPSY

Author Affiliations

PHILADELPHIA

From the Neurological Service and the Laboratory of the Philadelphia General Hospital and from the School of Medicine of the University of Pennsylvania.

Arch NeurPsych. 1923;9(4):431-435. doi:10.1001/archneurpsyc.1923.02190220017002
Abstract

Cases of Charcot-Marie atrophy with necropsy are sufficiently rare to warrant report. To date, six cases of this condition with the pathologic findings have been recorded; that reported by one of us (G. W.) is the only example from this country. The pathologic findings in the six cases have not been entirely uniform; all of them showed degeneration in the posterior columns, and in four of the six cases the peripheral nerves were diseased; in one slight degeneration was found in the peroneal nerves alone, and in one the nerve trunks were normal though the intramuscular filaments were altered. The anterior horn cells were greatly involved in one case, but the other five cases showed little alteration in the structure of these cells. Clark's columns were moderately affected in one case. The pyramidal tracts showed slight changes in two cases.

REPORT OF A CASE 

Clinical History.  —M. R., a single

×