Epidemic encephalitis and epidemic poliomyelitis are typical instances of acute inflammation of the central nervous system. In both conditions the entire nervous system is more or less involved, the mesencephalon principally in the former, and the spinal cord in the latter. The site of the lesion is thus the main aid in the histopathologic diagnosis of typical cases. In atypical cases, both the mesencephalon and the spinal cord may be involved, and such cases present great difficulties in differential diagnosis. In fact the similarity in localization, gross character and histology may be so great that, as Häuptli1 pointed out, they might be considered as identical processes.
However, it has been shown by clinical, serologic and possibly also bacteriologic studies that they are distinct morbid entities.
My studies of a case of acute anterior poliomyelitis (Landry's type) and of one of epidemic (lethargic) encephalitis have led me to the conclusion
HASSIN GB. A NOTE ON THE COMPARATIVE HISTOPATHOLOGY OF ACUTE ANTERIOR POLIOMYELITIS AND EPIDEMIC ENCEPHALITIS. Arch NeurPsych. 1924;11(1):28-42. doi:10.1001/archneurpsyc.1924.02190310034002