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In our work with diabetic children, we have always been impressed with the marked symptoms of depression shown by these patients. We have observed that the most noticeable reaction from the use of insulin was the clearing of the depression. This observation led us to make some investigations into the possible effect of insulin in states of true mental depression. Raphael and Parsons have shown that there is a disturbance of the normal utilization of glucose in manic-depressive psychosis. In the depressive phase, there is a delayed utilization of glucose comparable to that obtained in diabetes mellitus, while in the agitational phase the glucose utilization curve is flat or has a tendency to fall below that of a normal person. This would seem to indicate an increased utilization of glucose. The following investigations show the effect of insulin on the glucose absorption and utilization in the depressive phase of manic-depressive
COWIE DM, PARSONS JP, RAPHAEL T. INSULIN AND MENTAL DEPRESSION. Arch NeurPsych. 1924;12(5):522-533. doi:10.1001/archneurpsyc.1924.02200050037004