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March 1925

BLOOD SUGAR STUDIES IN EXPERIMENTAL PITUITARY AND HYPOTHALAMIC LESIONSWITH A REVIEW OF LITERATURE

Author Affiliations

ST. LOUIS; Fellow in Neurological Surgery, St. Louis, Mo., 1923-1924 BOSTON

From the Department of Surgery, Washington University School of Medicine, St. Louis, Missouri.

Arch NeurPsych. 1925;13(3):335-368. doi:10.1001/archneurpsyc.1925.02200090049002
Abstract

In September, 1923, Mrs. W. was operated on for an acute acromegaly due to an adenoma of the pituitary gland. Following the partial removal of the tumor by a lateral approach through a parietofrontal flap, she developed a moderate polyuria which lasted for three weeks and a glycosuria which lasted for ten days. The patient's sugar metabolism was studied by Dr. W. H. Olmsted, who reported that the glycosuria in no way differed from the glycosuria of a diabetic patient. The glycosuria was furthermore controlled by administration of insulin. A month after the operation, when given 100 gm. of glucose by mouth, the patient showed a sugar curve which reached its highest point at the end of the second hour, and with a blood sugar of 0.38 excreted sugar in the urine. A month later, when given 50 gm. of glucose, the blood sugar curve reached its maximum at the

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