Ever since Schilder's1 description in 1912 of a peculiar clinical and pathologic syndrome which he called encephalitis periaxialis diffusa, various continental observers have reported isolated examples of this rare and interesting disease. Recently, Collier and Greenfield2 of England and Bouman3 of Holland reported four instances with thorough clinical and pathologic investigation. Up to date, thirty-two observations of encephalitis periaxialis diffusa have been reported, and the reader is referred to the later articles, especially Bouman's, for detailed analysis of thirty of these cases.
A study of our case and the literature confirms the belief that we are dealing with a syndrome having a fairly typical course and pathology, which frequently should be capable of diagnosis during life. It may be pointed out that Collier recognized his second case during the patient's life. These English writers describe the disease as:
A malady usually occurring in children and young subjects
BROCK S, CARROLL PM, STEVENSON L. ENCEPHALITIS PERIAXIALIS DIFFUSA OF SCHILDERREPORT OF A CASE. Arch NeurPsych. 1926;15(3):297-308. doi:10.1001/archneurpsyc.1926.02200210018002