[Skip to Content]
[Skip to Content Landing]
Other
January 1927

FRIEDREICH'S ATAXIACLINICAL AND POSTMORTEM STUDY OF TWO CASES IN BROTHERS AT DIFFERENT STAGES OF THE DISEASE

Author Affiliations

PITTSBURGH

From the Graduate School of Medicine of the University of Pennsylvania and the Laboratory of Neuropathology, Philadelphia General Hospital.

Arch NeurPsych. 1927;17(1):28-43. doi:10.1001/archneurpsyc.1927.02200310031004
Abstract

Although reports of the occurrence of Friedreich's ataxia in siblings are not uncommon, rarely has an opportunity been presented for the clinical study during the different stages of the disease and of the spinal cord lesions in such cases. The cases here described were those of two brothers, fullblooded negroes, each of whom was 8 years of age when the symptoms were first observed. The duration of life, from the time of the onset of the illness, was three years in the case of one brother, and seven years in the case of the other.

The case of the elder brother was described by Lloyd and Newcomer,1 in 1921. At that time the younger brother was still alive. His death, in October, 1924, furnished the opportunity for the present comparison of the two cases.

REPORT OF CASES 

Case 1.—Family History.  —The parents were living and in good health. There

×