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March 1928

LOCALIZATION IN ANIMALS OF STREPTOCOCCI FROM CASES OF EPIDEMIC HICCUP, ENCEPHALITIS, SPASMODIC TORTICOLLIS AND CHOREA

Author Affiliations

ROCHESTER, MINN.

From the Division of Experimental Bacteriology, The Mayo Foundation.

Arch NeurPsych. 1928;19(3):424-436. doi:10.1001/archneurpsyc.1928.02210090050004
Abstract

In a series of reports published in the medical literature during the last eleven years, I have emphasized1 the importance in the etiology of diseases of the nervous system of certain streptococci having peculiar localizing power. The experimental results, while not always conclusive proof of etiologic relationship in each of the diseases studied, have furnished a good working hypothesis which already has led to a better understanding of the cause and management of the diseases studied.

In 1916, I reported2 a series of experiments in which lesions in the spinal cord or brain of animals, characteristic in situation, were produced by the intravenous injection of cultures containing streptococci from atria of the infection in cases of multiple sclerosis and transverse myelitis. Similar experiments in cases of neuralgia and multiple neuritis produced instead lesions chiefly in the dorsal nerve roots and peripheral nerves, respectively, in a high percentage of

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