Understanding of the acute changes which the interstitial cells of the central nervous system undergo has increased step by step with the improvement and simplification of cytologic methods. The newer impregnation methods of Cajal1 and Rio-Hortega2 serve to demonstrate the pathologic alterations in the supporting cells as clearly as they show their normal histologic detail and to demonstrate them in the same selective manner. With these specific methods the acute changes which the various cell groups undergo can be followed clearly. Many questions which had to be left unanswered because of inadequate staining methods can be settled.
Much of the work on the acute changes in the interstitial cells by the Spanish school of neurology has been done with the use of experimental material from animals. It has seemed worth while to present the acute changes as they are seen in material from human beings3 and to
CONE W. ACUTE PATHOLOGIC CHANGES IN NEUROGLIA AND IN MICROGLIA. Arch NeurPsych. 1928;20(1):34-72. doi:10.1001/archneurpsyc.1928.02210130037003