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October 1928

STUDIES IN EPILEPSYVII. THE BASAL METABOLISM

Author Affiliations

BOSTON

From the Neuropathological Department of the Harvard Medical School, the Thorndike Memorial Laboratory of the Boston City Hospital and the Monson State Hospital.

Arch NeurPsych. 1928;20(4):764-770. doi:10.1001/archneurpsyc.1928.02210160105008
Abstract

Oxygen is of fundamental importance in the metabolic processes of the body. Therefore, in any disease condition in which the question of metabolism is involved, it is important to know the rate of oxygen consumption.

Although many authors have stated their belief that in epilepsy there is deficient oxidation of tissues, there are few reports concerning the rate at which oxygen is consumed by persons who are subject to recurring attacks of convulsions. In thirty-two patients with epilepsy, Boothby and Sandiford1 found that 23 per cent had rates 10 per cent or more below normal. In thirteen patients, Bowman and Fry2 obtained readings all of which were within the limits of normal. Without presenting data, Nielson3 stated that in eighteen patients he obtained an average rate of minus 10 per cent. In contrast with these authors, many of whose patients showed subnormal rates, Talbot, Hendry and Moriarty

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