During the course of studies of the acid-base metabolism of epileptic children carried out some years ago with Ross and Tisdall1 and with Hamilton,2 data were obtained which suggest a disturbance of the volume of body fluid in this disease. The pretext used for briefly recalling these bits of evidence is the recent interest in the effect of the restriction of water in epilepsy which has been aroused by the work of Fay and of McQuarrie.
The data that will first be considered were obtained from fasting epileptic children.1 An item of the study of these children was an attempt to measure the factors of loss of body weight during fasting. The weight of body protein consumed, of course, can be estimated from the amount of nitrogen entering the urine. An estimation of the weight of fat burned can be derived from measurements of the ketone acid
GAMBLE JL. EPILEPSYEVIDENCES OF BODY FLUID VOLUME DISTURBANCE. Arch NeurPsych. 1930;23(5):915-919. doi:10.1001/archneurpsyc.1930.02220110077005