In the first paper of this series1 it was reported that both hypertonic and hypotonic solutions, when injected intravenously, caused an increase in the oxygen utilization of the brain, and this is believed to indicate a diminished volume flow of blood through the brain. To determine whether these changes were the result of the variations in cerebrospinal fluid pressure produced by the solutions injected or of a more general effect of the solutions on the circulation as a whole, two types of investigation seemed indicated, namely, determination of the effect of these solutions on the general circulation and of the effect of increased intracranial pressure produced by other means. The present report deals with the effects of intravenous injection of hypertonic and hypotonic solutions on the cardiac output and blood pressure.
Eighteen experiments were done, dogs being used in all experiments. Twelve of the animals were given morphine
HAMM L, PILCHER C. CEREBRAL BLOOD FLOWII. THE EFFECT OF INTRAVENOUS INJECTION OF HYPERTONIC AND HYPOTONIC SOLUTIONS ON THE CARDIAC OUTPUT AND BLOOD PRESSURE. Arch NeurPsych. 1930;24(5):907-912. doi:10.1001/archneurpsyc.1930.02220170027003