[Skip to Content]
[Skip to Content Landing]
Other
September 1931

BASOPHILIC ADENOMA OF THE HYPOPHYSIS WITH ASSOCIATED PLURIGLANDULAR SYNDROMEREPORT OF A CASE

Author Affiliations

CLEVELAND

From the Department of Surgery, the Lakeside Hospital.

Arch NeurPsych. 1931;26(3):593-599. doi:10.1001/archneurpsyc.1931.02230090126008
Abstract

The profound influence of the anterior lobe of the hypophysis on the other endocrine organs, and particularly on the gonads, has been clearly demonstrated during the past few years by numerous experimenters; notably by Smith and his collaborators,1 Evans and his co-workers,2 Zondek3 and Aschheim.4 It has been shown that precocious sexual maturity may be induced in immature animals (rats, mice, dogs and monkeys) of both sexes, both by means of frequently renewed transplants of fresh tissue from the anterior lobe and by the administration of extracts prepared from this tissue. This effect is much more rapid and striking in the case of the female; indeed, sucklings may be brought to maturity in from two to four days, as evidenced by great hypertrophy and hyperemia of the uterus; opening of the vagina, with vaginal cellular content characteristic of the estrum, and marked hypertrophy of the ovaries,

×