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June 1932

HISTOLOGIC DIAGNOSIS OF TUMORS OF THE BRAIN

Arch NeurPsych. 1932;27(6):1290-1297. doi:10.1001/archneurpsyc.1932.02230180019003
Abstract

I shall confine my comments to a discussion of the tumors of the brain substance, leaving to my colleague, Dr. Penfield, the presentation of tumors of the meninges.

The microscopic structure of tumors of the brain is infinitely varied, yet among their kaleidoscopic appearances certain family resemblances may be traced, even though they be as elusive as those of the Dinaric race. There are three great families—the medulloblastoma, the glioblastoma and the astrocytoma—which differ widely in age of onset, site of origin and biologic behavior.

THE TUMORS 

The Medulloblastoma.  —This is almost exclusively a tumor of the cerebellum of children. Its clinical evolution is rapid, the average length of life of the patient from the onset of the symptoms to death being about fifteen months. It is usually situated in the middle of the cerebellum, but projects into the fourth ventricle. It has an unusual tendency to invade the meninges

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