Numerous cases are on record of congenital malformations of the cerebellum in man associated with lesions in the pons and inferior olives. Certain ontogenetic generalizations have been drawn from these experiments of nature that have helped greatly in clarifying the related fiber tract connections of these three structures—cerebellum, pons and inferior olives—but considerable lack of agreement still exists. Are the olivocerebellar connections olivofugal or cerebellofugal, or both? Do the inferior olives stand in direct connection with the cerebellar cortex or rather with the dentate nuclei? Are there connections of the olives and accessory olives with the paleocerebellar cortex and with the central cerebellar medullary nuclei? These and many other questions of equal import still lack uncontroverted answers.
Little work of an experimental nature has been done up to the present in attempting to clarify these fundamental problems and work of this kind is beset with a number of almost insurmountable
ZIMMERMAN HM, FINLEY KH. CONGENITAL HYPOPLASIA OF THE OLIVOPONTOCEREBELLAR TRACTS. Arch NeurPsych. 1932;27(6):1402-1420. doi:10.1001/archneurpsyc.1932.02230180131008