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July 1932

EXPERIENCES IN THE TREATMENT OF MULTIPLE SCLEROSIS WITH QUININE HYDROCHLORIDE

Author Affiliations

NEW YORK

From the Neurological Institute and the Neurological Department of Columbia University.

Arch NeurPsych. 1932;28(1):125-131. doi:10.1001/archneurpsyc.1932.02240010133009
Abstract

Certain observations recently made in the treatment of multiple sclerosis with quinine hydrochloride form the basis of this report. Although several years will be required to appraise the merits of this form of therapy, some of the results already obtained from it suggest that it may be of value. It is true that the evaluation of all therapeutic results in multiple sclerosis is seriously complicated by the nature of the disease itself. Chief among these complications are those incident to the spontaneous remissions, as well as the progressive advance of many symptoms to a point beyond relief by therapeutic measures.

Some recent experimental evidence gave indications that the lesions in multiple sclerosis may be due to abnormal lipolytic activity of the blood on the myelin in the nervous system. These experiments1 were based on the degree of myelinolysis which resulted from the immersion of the spinal cords of rats

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