A variety of necrobiotic agents has been employed to supplement the surgical removal of malignant tumors. Of these, Zenker's fluid has been used in the operative field of tumors of the brain, especially gliomatous cysts, and Cushing1 has recently emphasized its value, particularly for its hemostatic properties. In reviewing the literature, we have failed to find any experimental investigation of the relative merits of the various fixing agents used for this purpose. Zenker's fluid would seem particularly unsuited because of its slow penetration as compared to other commonly used fixatives.
This investigation was undertaken to test the necrobiotic and hemostatic properties of several of the more commonly used fixatives. For this purpose cysts were experimentally produced in the brains of dogs, and the various agents were tested on the lining of these cysts.
EXPERIMENTAL PRODUCTION OF CYSTS IN THE BRAINS OF DOGS
—Healthy, adult dogs were used. The
ZOLLINGER R, MORITZ AR. EFFECTS OF NECROBIOTIC AGENTS ON THE WALLS OF CYSTS EXPERIMENTALLY PRODUCED IN THE BRAINS OF DOGS. Arch NeurPsych. 1932;28(5):1046-1055. doi:10.1001/archneurpsyc.1932.02240050080005