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December 1932

CEREBRAL CIRCULATIONXVIII. EFFECT OF CAFFEINE ON CEREBRAL VESSELS

Author Affiliations

BOSTON

From the Neurological Unit, Boston City Hospital, and the Department of Neuropathology, Harvard Medical School.

Arch NeurPsych. 1932;28(6):1290-1325. doi:10.1001/archneurpsyc.1932.02240060049003
Abstract
  • Survey of the Literature

    1. Effect on Amphibians

    2. Effect on Mammals

      • Size of Blood Vessel

      • Blood Pressure

      • Heart Rate

      • Autonomic Nervous System

  • Original Experiments

    1. Experiments During Amytal Anesthesia

      • Effects After Intravenous Administration

      • Effects After Local Administration

    2. Experiments During Ether Anesthesia

      • Effects After Intravenous Administration

      • Effects After Local Administration

    3. Experiments After Recovery from Ether Anesthesia

      • Effects After Intravenous Administration

      • Effects After Local Administration

    4. Effects of Caffeine, on Animals with Low Blood Pressure

      • Experiments During Amytal Anesthesia

  • Comment

  • Summary

SURVEY OF THE LITERATURE  The effect of caffeine and its compounds on circulatory phenomena has long been of interest to physiologists, pharmacologists and clinicians. Since the isolation of the drug in 1820 by Runge, research has piled on research, until at present the literature is extensive. Stuhlman and Falck1 not only mentioned this fact, but enumerated fifty-one articles published between 1820 and 1856. Most of the study has been centered on

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