The objective in the analytic studies herein reported was to ascertain whether chlorine was displaced from the blood into other body fluids or eliminated in the urine to compensate for the accumulation of the bromine in the blood and any other body fluids following the ingestion of bromide by mouth. Comparative analyses for chlorine and bromine were made in the blood, spinal fluid and urine of a group of sixteen female epileptic subjects who had received chloride-bromine treatment for one year or more and all of whom exhibited a satisfactory physiologic response to the therapy. Details of the relative quantities of bromide and chloride fed to the epileptic patients have been presented by one of us (Dr. Notkin1) in an earlier publication. There also was described the method adopted for the analyses reported in this communication.
Twenty milliliters of blood, 100 ml. of urine and the maximum quantities
NOTKIN J, GARCIA T, KILLIAN JA. HALOGEN BALANCE OF BLOOD, SPINAL FLUID AND URINEIN PATIENTS WITH CONVULSIVE STATES ON BROMIDE-CHLORIDE THERAPY. Arch NeurPsych. 1933;30(1):114-122. doi:10.1001/archneurpsyc.1933.02240130122007