In a recent clinical study on the symptomatic involvement of the nervous system in different forms of dysentery1 we decided to consider one group of manifestations in the clinical neuropsychiatric picture as probably due to inflammatory processes; in this group we had especially in mind cases of myelitis and cases in which the condition clinically resembled closely the well known picture of epidemic encephalitis. Indeed, there exist cases with disorders of sleep, reflex disorders and more or less mental confusion or only dulness which, if no gastrointestinal symptoms were present, nobody could be blamed for diagnosing as cases of encephalitis. Sometimes also in clinical cases these nervous disorders precede the gastro-intestinal symptoms, as in Tupa's2 experiments on animals.
Another group seemed to be merely "toxic," which term refers especially to some patients with symptomatic psychotic behavior; but we emphasized that the term toxic should be subjected to analysis.
ALEXANDER L, WU TT. CEREBRAL CHANGES IN GASTRO-INTESTINAL INFECTIONS WITH TERMINAL CACHEXIAHISTOPATHOLOGIC STUDIES ON DYSENTERY, WITH COMMENTS ON SIMILAR OBSERVATIONS IN INTESTINAL TUBERCULOSIS. Arch NeurPsych. 1935;33(1):72-122. doi:10.1001/archneurpsyc.1935.02250130078005