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February 1935

EXPERIMENTALLY PRODUCED CONVULSIONSEFFECT ON THUJONE CONVULSIONS OF INSULIN AND OF VARIATIONS IN WATER CONTENT OF BRAIN

Author Affiliations

MONTREAL, CANADA

From the Department of Neurology and Neurosurgery, McGill University, Montreal.

Arch NeurPsych. 1935;33(2):353-359. doi:10.1001/archneurpsyc.1935.02250140109008
Abstract

During the past five years, since the reports of Fay1 and MacQuarrie2 in regard to the relationship of the water balance of the body to the occurrence of epileptiform seizures, there has been a great deal of interest in hydration, dehydration and the water content of the tissues. In previously reported experiments3 I have shown that rapid dehydration decreases the rabbit's susceptibility to experimental convulsions. The present paper deals with attempts to increase this susceptibility to convulsions by inducing "hydration" of the brain tissue and by the use of insulin and the induction of hypoglycemia.

MacQuarrie carried out experiments on epileptic children, giving them large amounts of water by mouth, accompanied in some cases by posterior lobe pituitary solution. He noted an increase in the number and severity of the epileptic attacks when the water was retained in the body in excessive amounts, and a reduction in

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