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June 1935

QUININE THERAPY IN CASES OF MULTIPLE SCLEROSIS OVER A FIVE YEAR PERIOD

Author Affiliations

NEW YORK

From the Neurological Institute and the Department of Neurology, College of Physicians and Surgeons, Columbia University.

Arch NeurPsych. 1935;33(6):1235-1254. doi:10.1001/archneurpsyc.1935.02250180094005
Abstract

The study of quinine therapy in cases of multiple sclerosis has been in progress for five years. In an earlier report,1 presented about fourteen months after the study was commenced, it was stated that quinine therapy appeared to have promise. The experience of five years with forty-nine patients seems to justify the conclusion that quinine is beneficial in cases of multiple sclerosis, particularly in the early stages.

The hypothetic and theoretical grounds for the employment of quinine were outlined in the communication referred to. They may be briefly recapitulated as follows: Marburg's idea that the lesions in cases of multiple sclerosis might be produced by the action of a circulating lipolytic agent was adopted as a working hypothesis, and experiments were undertaken to test its value. These experiments have given evidence supporting the idea, although they are still not completed. It had already been discovered that some lipases of

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