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November 1935

EXPERIMENTAL CONVULSIONS INDUCED BY ADMINISTRATION OF THUJONEA PHARMACOLOGIC STUDY OF THE INFLUENCE OF THE AUTONOMIC NERVOUS SYSTEM ON THESE CONVULSIONS

Author Affiliations

MONTREAL, CANADA

Arch NeurPsych. 1935;34(5):1022-1040. doi:10.1001/archneurpsyc.1935.02250230094008
Abstract

The use of absinth in the production of experimental convulsions in animals was first devised by Marcé1 in 1864; since that time it has been used extensively by numerous workers. Thujone is the chief constituent of the volatile oil of absinth which is obtained from the leaves of Artemisia absinthium (wormwood). It is a dextrorotatory ketone, thalviol tanacetone, with the formula C10H16O (Sollmann,2 Hackh3); it was first used as a convulsant by Cobb4 in 1922, and since then by Florey,5 Sparks,6 Lennox, Nelson and Beetham,7 Keith8 and others.

Experimental convulsions brought about by the administration of thujone closely resemble true epileptiform seizures and have been shown to originate in the central nervous system. It has been repeatedly demonstrated by Gotch and Horsley,9 Boyce,10 Bouché,11 Horsley,12 Hill,13 Elsberg and Stookey14 and others that

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