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June 1936

VASCULAR CHANGES FOLLOWING EXPERIMENTAL LESIONS IN THE CEREBRAL CORTEX

Author Affiliations

CHICAGO

From the psychologic laboratory, the University of Chicago.

Arch NeurPsych. 1936;35(6):1280-1288. doi:10.1001/archneurpsyc.1936.02260060122010
Abstract

There are at least three possible causes of disturbances of behavior after an injury to the cerebral cortex. First, the functional organization may be disturbed by direct damage to the nerve elements involved. Second, the destruction of cells in one region may result in functional disturbances in cells in other regions by diaschisis. Third, the metabolism of adjacent or even remote parts may be disordered by alteration of the vascular supply. Vascular changes may not coincide with the region of direct damage to nerve cells. In general, vascular deficiency in a cortical field always implies functional abnormality, although a functionally abnormal area does not necessarily mean the presence of vascular disturbance. In the case of a lesion with actual removal of tissue, there is always a zone bordering the site of the operation in which both cellular and vascular changes are apparent. The present study was made in an attempt

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