Since the pioneer work of Broca and of Fritsch and Hitzig, there has been a steady accumulation of evidence for the anatomic and functional specialization of different cerebral areas. Diversities of cortical structure revealed by myelino-architectural and cyto-architectural studies have been correlated with differences in subcortical connections and with consistent and characteristic symptoms of defect following local injuries. The principal sensory and motor areas have been delimited, and the problem of cerebral localization has become one of the degree of specialization within cyto-architectural areas, of the nature of the functional disturbances following various types of injury and of the mechanisms of organization.
Behind these questions of detail and interpretation there remains, however, the problem of the functional significance of all localization. The basis of localization of function within the nervous system is apparently the grouping of cells of similar function within more or less isolated nuclei or fields. The fundamental
LASHLEY KS. FUNCTIONAL DETERMINANTS OF CEREBRAL LOCALIZATION. Arch NeurPsych. 1937;38(2):371-387. doi:10.1001/archneurpsyc.1937.02260200143013