The location of the temperature-regulating center has formed the subject of many investigations. The work of Isenschmid and Schnitzler1 has given what seems to us reliable information. They showed that small bilateral lesions in the region of the mammillary bodies and the posterior part of the tuber cause loss of the capacity to guard the body against abnormal drops in body temperature. More recent work has established beyond dispute the importance of the hypothalamus for regulation of temperature, but there is a great deal of difference of opinion as to the exact location of the center or centers involved (Alpers;2 Bazett, Alpers and Erb;3 Bazett and Penfield;4 Davison and Selby;5 Dworkin;6 Frazier, Alpers and Lewy;7 Glaubach and Pick8 Keller:9 Keller and Hare,10 and Solari11).
Observations made on animals decerebrated at various levels are not altogether satisfactory because so much
RANSON SW, FISHER C, INGRAM WR. HYPOTHALAMIC REGULATION OF TEMPERATURE IN THE MONKEY. Arch NeurPsych. 1937;38(3):445-466. doi:10.1001/archneurpsyc.1937.02260210011001