Despite the extent of the literature on therapeutic research in schizophrenia, the psychosis has been essentially unmodifiable by external means. As long as the underlying pathobiologic processes are not known treatment can be only empirical; perhaps through actually discovered correlations the starting point for an effective therapeusis may be achieved, as in the case of dementia paralytica and pernicious anemia.
Sakel's treatment differs from all previous therapeutic attempts in that its goal is the daily production in each patient of profound hypoglycemic coma. America has been rather tardy in investigating the new treatment, although during the last year articles have begun to appear and insulin shock therapy has been started in many places. It must be stated at the outset that this procedure is not to be played with. Though fatalities are rare, the patient is always in a more or less precarious state during deep hypoglycemia. Moreover, the response
REESE HH, VEER AV. EXPERIENCES WITH INSULIN SHOCK THERAPY IN SCHIZOPHRENIA. Arch NeurPsych. 1938;39(4):702-716. doi:10.1001/archneurpsyc.1938.02270040058003