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October 1938

STUDIES IN DISEASES OF MUSCLEIV. METABOLISM OF CREATINE AND CREATININE IN MUSCULAR WASTING SUBSEQUENT TO DISEASE OF THE NERVOUS SYSTEM

Author Affiliations

With the Technical Assistance of V. Toscani, B.S. (Chem.) NEW YORK

From the New York Hospital; the Department of Medicine, the Cornell University Medical College, and the Russell Sage Institute of Pathology.

Arch NeurPsych. 1938;40(4):663-679. doi:10.1001/archneurpsyc.1938.02270100035002
Abstract

Creatinuria and diminished excretion of urinary creatinine are common findings in patients with muscular wasting subsequent to disease of the nervous system. As early as 1909 Levene and Kristeller1 observed that some patients with muscular involvement of this kind excrete creatine and have a lowered creatinine output. Many investigators have confirmed these findings and have extended the observations to various types of muscular wasting. However, understanding of the mechanism of creatinuria in these conditions is not yet clear. Furthermore, it is not known whether the factors influencing the metabolism of creatine and creatinine associated with muscular wasting subsequent to a lesion of the nervous system are similar to those which determine the excretion of creatine and creatinine in progressive muscular dystrophy (Milhorat and Wolff2).

MATERIAL AND METHODS  In the present investigation 17 patients with muscular wasting due to a variety of conditions were studied. The group included patients

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