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June 1939

STUDIES IN DISEASES OF MUSCLEVIII. METABOLISM OF CALCIUM, PHOSPHORUS AND MAGNESIUM IN PROGRESSIVE MUSCULAR DYSTROPHY, MYOTONIA ATROPHICA AND FAMILIAL PERIODIC PARALYSIS

Author Affiliations

NEW YORK

From the New York Hospital and the Department of Medicine, Cornell University Medical College, and the Russell Sage Institute of Pathology.

Arch NeurPsych. 1939;41(6):1130-1137. doi:10.1001/archneurpsyc.1939.02270180058005
Abstract

Although there is considerable evidence of the importance of calcium, phosphorus and magnesium in the chemical processes in voluntary muscle, no adequate studies of the metabolism of these substances in patients with muscular disease have heretofore been made. In the present investigation the metabolism of these minerals was studied in 4 patients. There were 2 patients with progressive muscular dystrophy, 1 with myotonia atrophica and 1 with familial periodic paralysis. In addition, the metabolism of calcium and phosphorus was investigated in another patient with myotonia atrophica, but the studies were not as extensive. Since the findings are in essential agreement with those on the other patient with this condition, they are not included in this report.

METHODS  The patients were kept in a special metabolism ward where careful collections of urine and feces could be made and where the diets were rigorously supervised. The mineral balance, for different levels of

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