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July 1939

STUDIES IN MONGOLISMIII. THE PITUITARY BODY

Author Affiliations

WRENTHAM, MASS.

From the Research Department for the Study of Mental Deficiency, Wrentham State School and the Department of Neuropathology, Harvard Medical School.

Arch NeurPsych. 1939;42(1):1-20. doi:10.1001/archneurpsyc.1939.02270190009001
Abstract

In the previous paper dealing with the role of the thyroid in mongolism, I pointed out that involutional changes were observed in all my cases. One may distinguish between the histologic structure of the thyroid of mongoloid children in the first two years of life and that of mongoloid children after the first six years. In the former group irregular parenchymatous growth without formation of vesicles and a number of greatly enlarged tubules and marked increase of connective tissue prevail; in the latter group distention of vesicles with colloid and invasion of colloid in the intertubular spaces are conspicuous, while the thyroid as a whole is small and underdeveloped. I pointed out that there may be premature stimulation of the thyroid, even hyperthyroidism, during fetal life, but after birth onefinds only involutional changes and hyperactivity appears to be replaced by degenerative processes. Such a picture is suggestive of a disorder

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